This website uses cookies to ensure you have the best experience. Learn more

Resistance Mechanism Btk Review

353 words - 2 pages

Bio 242 AM
Reading Report 1
May 29th, 2014

Paper reviewed: Woyach, J.A. et al. 2014. Resistance mechanisms for the Bruton’s tyrosine kinase inhibitor ibrutinib. NEMJ. DOI: 10.1056/NEJMoa1400029

Summary of paper:
Ibrutinib acts as an irreversible inhibitor of Bruton’s tyrosine kinase (BTK) that induces a modest amount of chronic lymphocytic leukemia (CLL) cell apoptosis stopping B-cell receptor signaling and proliferation in vitro. Ibrutinib has been shown to have clinically significant activity in patients with relapsed CLL with 71% of patients ...view middle of the document...

A cysteine-to-serine mutation in BTK at the biding site was found along with three gain-of-function mutations that are downstream from the BTK binding site that lead to autonomous B-cell receptor activity.

Bias of paper:
The paper was not biased. Research was funded by Funded by the National Cancer Institute and other institutions. No conflicts of interest were included in this paper.

Conclusion supported?
Mutations of BTK binding site and B-cell receptor pathways in this study suggest that BTK is a critical target for the mechanism action of Ibrutinib. More knowledge of down stream mediators of Ibrutinib resistance can help to develop prevention and treatment of BTK inhibitor resistant CLL. However, more studies will need to be done to illustrate the statistical significance of this paper as this study only looked at a sample of 6 patients with acquired resistance to Ibrutinib therapy.

Relevance/Importance of research:
Understanding the overall effect of BTK inhibitors on treatment of patients with CLL, and the potential to cause resistance to valuable treatment avenues is very significant. The American Cancer Society estimates that there will be approximately 15,720 new cases and 4,600 deaths in the US in 2014 from CLL.

Other assignments on Resistance Mechanism Btk Review

Fundamental Analysis Of Power Sector

6757 words - 28 pages is “Midgets or Small Power Plants” and “CDM—Clean Development Mechanism”. India and Infrastructure With traditional government controlled vertically integrated monopoly giving way for new multi-player market-driven scenario, the opportunity in power sector attracted entrepreneurs into the sector. The ever-growing demand gap asked for addition of 1000 MW generation capacity per year. These forces coupled gave rise to different strategies that

The Impacts Of Recruitment Practice At Commercial Bank Of Ethiopia

4308 words - 18 pages study finding. 1.4 Methodology of the Study Data for this study were derived from secondary sources: previous research and analysis of scholars, government documents, newspaper/magazines as well as journal articles that are related to the subject. This study involved an extensive literature review which critically analyzed the present status, problems and prospects of recruitment in Commercial Bank of Ethiopia. 1.5 Significance of the Study

Supplier Selection

7844 words - 32 pages resistance requirements, but not specify the particular composition of the material. Suppliers respond to the RFP with details on how they would satisfy the buyer’s performance requirements and the price they would be willing to accept to do so. 6 Upon learning the supplier’s proposed pricing, the buyer may revise its requirements and/or negotiate exact terms with suppliers. Thus, the process is generally iterative. An RFP is appropriate for

Gender Empowerment And Development

6049 words - 25 pages crown 1987). GAD The approach dues not focus singularly on productive or reproductive aspects other. of women's (and men's) lives to the exclusion It analyses the nature of women's contribution context of including work done both inside and outside non-commodity production, the of within the the household, and rejects the public/private dichotomy which commonly has been used as a mechanism to undervalue family and

Cryptography

7926 words - 32 pages -based or address-based, both of which are notoriously weak.) * Privacy/confidentiality: Ensuring that no one can read the message except the intended receiver. * Integrity: Assuring the receiver that the received message has not been altered in any way from the original. * Non-repudiation: A mechanism to prove that the sender really sent this message. Cryptography, then, not only protects data from theft or alteration, but can

Treatment Of Cbt Did

7725 words - 31 pages firefighters, exiles, and managers provides the DID client a concrete framework upon which he or she can build the process of integration of the fragmented parts or alters. The IFS model is an efficient way to work with resistance and denial, which are often displayed by firefighters and exiles. The language of parts in this framework allows for the mapping of alters in a nonjudgmental way, which helps in self-disclosure. The communication between alters

Mgt216

714 words - 3 pages The first ethical issue presented in the ethics game simulation was whether to warn consumers about the contaminated product and what information to provide consumers about the contaminant. The second ethical issue was whether to sell a product that does not meet U.S. safety requirements in a foreign market that has lower safety restrictions. G-BioSport was not required to meet prior approval from the Federal Drug Administration before they

Economy Effect Of Marijuana

277 words - 2 pages Modern American History by Alan Renga 2nd Mid Term! You will be given 3 Short Essay questions and 20 Multiple Choice questions deriving from this list! 80 points total! The 1920s Warren Harding then Calvin Coolidge Tea Pot Dome 1st Red Scare Immigration Restriction, Sacco and Vanzetti Langston Hughes, Marcus Garvey, KKK Prosperity, advertising Prohibition, Al Capone Flappers, Clara Bow, Rudolph Valentino Babe Ruth, Jack Dempsey

The Vc Shakeout

2033 words - 9 pages and studied the latest data from principle VC industry analysts to understand why venture capital has fallen so far. How did the industry that made computers ubiquitous, July–August 2010 Harvard Business Review 21 IDEA WATCH What We’re Watching in... With Customers, Any Compliment Will Do... In a simple but striking experiment, students who were identified as would-be clothing shoppers received an overtly flattering flyer from a fictitious

Hospitals Paper

6014 words - 25 pages department to which he/she wants to practice in. Then if approved it is sent to the Chief Medical officer who will review the application again. If it is found worthy it proceeds up to the board that will review and credential the application to make sure the physician meets their standards and has good qualifications. If they pass the board is the one who has the power the grant staff privileges. All major decisions that have to do with the hospital

Course Syllabus

2610 words - 11 pages . | |Course Prerequisites |COMPASS Placement Test or grade of “C” or better in Math 98 or equivalent. | |Course is Expected to |This course is intended for students who lack credit in one year of high school algebra or desire a review of the subject | |Serve |matter

Similar Documents

Change Leadership Essay

5140 words - 21 pages a vision of the change process can reduce the error rate. And fewer errors can spell the difference between success and failure."-(Kotter, 1995) 6.References Jackson, B. & Parry, K. (2008) A very short, fairly interesting and reasonably cheap book about studying leadership. London: Sage Kotter, JP 1995, 'Leading Change', Harvard Business Review, 85, 1 (2007), pp. 96-103 UMBLE, M, & UMBLE, E 2014, 'Overcoming resistance to change', Industrial Management, 56, 1, pp. 16-21 Sirkin, H.L, Keenan, P. & Jackson, A. (2005) 'The hard side of change management', Harvard Business Review, 83 (10), pp.108-118.

Ol Keywords Essay

4081 words - 17 pages • Morality • time 6. What is disclosure mechanism Ans: ‘Whistle-blowing’ is the term used to define an individual’s decision to disclose the information regarding unethical, immoral or illegal to an authority. Whistle-blowing entails revealing wrongdoing or improper conduct within an organization to those in authority or to the public 7. What is learning organization

State Led And Market Assisted Land Reforms

4318 words - 18 pages doing, the state will provide supporting services such as resource development, marketing facilities as well as public utilities (SEAMEO: 2009). Market-led land reform denotes equal access to land asset through the market mechanism in order to promote efficient resource allocation. Market-led land reforms (also market-assisted, market-driven, market-friendly or negotiated land reforms) have been initiated to indicate strategies that intend to

Strategic Planning Essay

4766 words - 20 pages community in creating a new IT vision tied to the campus mission; develop an IT strategic plan that effectively organizes objectives, priorities, projects, resources, and timelines to implement the vision Communication Plan: Constantly inform the campus community about the vision and status of the IT strategic plan Accountability: Develop a monitoring, evaluation, feedback, and formal assessment mechanism to constantly review and revise the plan Draft: Strategic Planning – 11/17/06 17