This website uses cookies to ensure you have the best experience. Learn more

Pg Mm Essay

717 words - 3 pages

ANSWER THREE OF THE QUESTIONS

ALL QUESTIONS SHOULD BE ANSWERED IN A SEPARATE BOOKLET

Answer all parts of the chosen questions. All questions are for 22 marks.

1. (a) Discuss the design of a pharmacogenomic study, including pharmacokinetic and pharmacodynamic aspects, to evaluate the variability in response to warfarin in populations with different ancestries. [ 11 marks ]

(b) Describe 2 different enzymes affecting pharmacokinetic factors and drug response. Include drug substrates, disease(s) implicated, their genetic variations and explain how the knowledge of genotype/phenotype relationship could be useful in clinical practice.
[ 11 marks ]

...view middle of the document...

[ 11 marks ]

Pharmacogenomics is the study of how the variability of the expression of genes between people leads to differences in susceptibility to disease and responses to medicines. 

http://www.crc.gov.my/newsletter/newsletter-issue-3/national-committee/423

http://www.admin.cam.ac.uk/offices/research/documents/local/events/downloads/pm/Stephen_Little.pdf

b) What are the ethical issues surrounding the use of pharmacogenomic information in clinical medicine. Focus on the following stakeholders:
(i) the patient (and their family)
(ii) the medical practitioner
(iii) the health board paying for the treatment
(iv) the pharmaceutical/ biotechnology industry
(v) health insurance companies [ 11 marks ]

http://www.genomichealthcarestrategies.com/pdfs/tips_july2000.pdf

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2376080/

http://www.scu.edu/ethics/practicing/focusareas/medical/pharmacogenomics.html

http://archive.ispub.com/journal/the-internet-journal-of-law-healthcare-and-ethics/volume-6-number-1/applying-existing-ethical-principles-to-personal-medicine.html#sthash.UjeF7nMj.dpbs

5. (a) Describe how the polymorphisms in CYP450 genes can affect drug response, adverse effects and individual treatment. Give two examples. [ 11 marks ]

(b) Giving a specific example, describe the identification of genetic markers for a drug-induced hypersensitivity reaction (‘off-target’...

Other assignments on Pg Mm

Pfier Wyeth M&A Transaction Analysis

8308 words - 34 pages 34.2% Premium to 1/23/09 WYE price 29.3% Total Consideration $67,303 100.0% Total WYE shares (MM,diluted) 1,341 Total Equity Value $68,001 Total Enterprise Value $65,339 Exhibit 3: Summary of Terms, PFE Acquisition of WYE at $50.19 per share (Per Credit Suisse Analyst Report) Synergy Effects for the Pfizer and Wyeth Combined Firm: 1. Forming the world’s

Power Essay

9021 words - 37 pages sequential elements is honored (Fig. 6), hold timing constraints are applied on the sequential elements to enable the EDA tool to balance the isolation control signal path and prevent the ISOLATE signal from triggering too early. The Cortex-M0 together with the proposed SCPG technique was part of a 2 mm × 2 mm system on chip (SoC) Fig. 7. Design flow of SCPG. which is shown on the right in Fig. 8. The entire CortexM0 microprocessor

Mgt216

714 words - 3 pages The first ethical issue presented in the ethics game simulation was whether to warn consumers about the contaminated product and what information to provide consumers about the contaminant. The second ethical issue was whether to sell a product that does not meet U.S. safety requirements in a foreign market that has lower safety restrictions. G-BioSport was not required to meet prior approval from the Federal Drug Administration before they

Economy Effect Of Marijuana

277 words - 2 pages Modern American History by Alan Renga 2nd Mid Term! You will be given 3 Short Essay questions and 20 Multiple Choice questions deriving from this list! 80 points total! The 1920s Warren Harding then Calvin Coolidge Tea Pot Dome 1st Red Scare Immigration Restriction, Sacco and Vanzetti Langston Hughes, Marcus Garvey, KKK Prosperity, advertising Prohibition, Al Capone Flappers, Clara Bow, Rudolph Valentino Babe Ruth, Jack Dempsey

The Vc Shakeout

2033 words - 9 pages ECONOMY 26 Luring a big firm to town is not the secret to job growth DEFEND YOUR RESEARCH 30 Are morning people wired for success? VISION STATEMENT 32 The social web’s east-west divide COLUMN 38 Warren Bennis looks back on his surprising path to fame New Thinking, Research in Progress hbr.org New Thinking, Research in Progress hbr.org FIRST The VC Shakeout Venture capital hasn’t worked for a decade and must be radically

Hospitals Paper

6014 words - 25 pages I hope to provide in this paper a comprehensive understanding for what the term “hospital” has become. Hospitals are an extremely complex system that man has created and shaped and reshaped throughout history. My goal in writing and researching this paper will be to provide those who read it a clear understanding on how the hospital system got to where it is today, and to shed some light on the many organizations that affiliate with and

Course Syllabus

2610 words - 11 pages [pic] COURSE SYLLABUS Semester: Fall, Year: 2012  College Mission Statement Richard J. Daley College provides high-quality education which leads to academic success, career development, and personal enrichment that fulfill diverse community needs. Mathematics Department Mission Statement Our mission is to deliver excellent service and to provide learning opportunities by offering a wide range of mathematics courses, which will help our

Management

1477 words - 6 pages Boeing Management Planning Heather Oetzel MGT 330 October 22, 2012 Joe Cheng Abstract Boeing is known as “the world’s leading aerospace company and the largest manufacturer of commercial jetliner and military aircraft combined ("The Boeing Company: About Us", 2012). Every company uses different types of management techniques including how the planning function of management is used. Planning allows organizations to develop how the

Assisted Suicide

1015 words - 5 pages Should physician-assisted suicide be legal? While I believe if one chooses to end his or own life through physician assistance for reasons that they chose, the choice should be up to the individual. Physician-assisted suicide should be at one's discretion. “Assisted Suicide, also called Voluntary Euthanasia, is currently a contentious issue in many countries. Because Euthanasia is legal in a few modern democracies: the Netherlands, Belgium

Tanglewood Case 1

797 words - 4 pages Tanglewood’s staffing strategy requires the organization to make key decisions about the acquisition, deployment, and retention of the organization’s workforce. In order to accomplish this, Tanglewood’s must make thirteen decisions regarding its staffing levels and its staffing quality. One of the first decisions that Tanglewood needs to choose is to acquire or develop talent. Tanglewood should try to develop their current talent because one

Nnnnn

1391 words - 6 pages Есе по въпроса: Кои от всички „действащи” лица могат да се разглеждат като морално отговорни и в какво именно? по казуса Форд „Пинто” Корпоративните злодеяния са нанесли повече вреди на обществото от всички улични престъпления взети заедно. Според данни на ФБР сумата от уличните престъпления възлиза на $3.8 млрд. годишно, а загубите от корпоративните измами между $100 млрд. и $400 млрд. годишно

Similar Documents

Maligant Melonomia Essay

2505 words - 11 pages | Table of Contents Definition Pg. 1 Introduction Pg. 1 Signs and symptoms Pg. 1-4 Pathophysiology( Intrinsic factors) Pg. 4-5 Environmental factors Pg. 5-6 Types of Melanoma Pg. 6-7 4 Stages and Evolution of Melanoma Pg. 7-9 Prevention of Melanoma Pg. 9 References Pg. 10 Definition Malignant melanoma is a neoplasm of melanocytes or of the cells that develop from melanocytes

Motor Learning Theory Essay

918 words - 4 pages is used to solve a problem. KR is the verbal component of Adams theory, which according to him, is key for motor learning to occur. Next, is his idea of the perceptual trace. According to Adams (1971, pg. 123) in order to move a limb, a reference of past movement is necessary (i.e. the perceptual trace), KR, and sensory feedback. The perceptual trace is almost the “memory” of past movement. It is weak in the beginning of a new movement, and

Casereport

848 words - 4 pages , this leads to quick and current ratios of 12.2 and 12.8 respectively (Appendix), and a debt ratio of 7.5. This figure indicates that assets far exceed liabilities in the short and long term, proving that the company has sufficient liquidity and long-term solvency. Additionally, as Linear CFO Paul Coghlan has indicated that he had âno plans for acquisitionsâ (Pg 3), all factors point to the absence of any requirement for external financing

Pepsico Essay

2290 words - 10 pages . Criticisms of the MM Model and Assumptions……………7-8 VIII. PepsiCo’s Capital Structure……………………………………….8-9 IX. Conclusion…………………………………………………………………..9 X. Refrences…………………………………………………………………..10 ABSTRACT The following research will examine the capital structure of Pepsico and how the choices that the company makes affects their return on investment and their risk profile. The traditional theory of capital structure theorizes, “when the